Nuffield Department of Clinical Medicine

The Nuffield Department of Medicine (NDM) is a large multi-disciplinary Department that links high quality basic biological science with medical application. Led by Professor Peter Ratcliffe FRS, who is both an active researcher in cell biology and an active clinician, the Department employs in the region of 1000 scientific research staff working in a range of basic science and clinical disciplines. Our researchers contribute to the teaching of 450 medical students within Oxford University's Clinical School. Our base at the Headington Hospitals campus, Oxford, is now one of the largest centres for biomedical research in Europe with over £200M invested in capital projects and research infrastructure over the last decade. The rapidly growing campus provides a vibrant, highly interactive environment for research development. We are particularly committed to the career development of young scientists, including those from basic science as well as clinical backgrounds. In 2006 the Oxford University / Oxford Radcliffe Hospital Trust partnership successfully competed to be one of five UK Biomedical Research Centres. We played a leading role in this initiative, which provides a range of new opportunities for basic scientists to interact with clinical medical research, and for career development of clinician scientists. In addition to its Oxford base, the Department operates a number of major overseas programmes in tropical medicine and global health, with research units in Thailand, Laos, Vietnam and Kenya supporting activities at numerous sites in S-E Asia and Sub-Saharan Africa. We also operate extensive epidemiological and clinical trials networks throughout China, India and South America. In Oxford, NDM maintains research platforms across structural biology, protein biochemistry, genetics, genomics, proteomics, cell biology, chemical and genetic screening, imaging, bioinformatics, medical statistics, epidemiology, and clinical trials. Thematic research includes cancer biology, immunology, vaccinology, infectious diseases, gastroenterology, dermatology, diabetes and metabolic medicine, renal medicine, respiratory medicine, stroke medicine, and geratology.

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Title	Description	People	Date
Personalised Medicine	Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries in diagnosis or treatment of medical conditions.	Jenny Taylor	9 February, 2015
Cancer predisposition and evolution	Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers grow also helps develop improved treatments.	Ian Tomlinson	9 February, 2015
Cancer Informatics	Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients.	Benjamin Schuster-Böckler	9 February, 2015
Pharmacogenomics	Dr Sebastian Nijman develops new approaches to study signalling networks in cancer cells and uncover specific weaknesses, particularly in breast and lung cancer. This can be used to develop more effective drugs and to better guide treatment decisions.	Sebastian Nijman	9 February, 2015
Cambodia Oxford Medical Research Unit (COMRU)	This video introduces COMRU, the Cambodia Oxford Medical Research Unit, a collaboration between the Angkor Hospital for Children and Bangkok-based Mahidol Oxford Tropical Medicine Research Unit (MORU).	Paul Turner, Claudia Turner	16 December, 2014
Shoklo Malaria Research Unit (SMRU)	Filmed in April 2013 at the Shoklo Malaria Research Unit (SMRU) in Mae Sot, and at the Wang Pa Free Clinic and the Mae La refugee camp, this video highlights SMRU's work among Karen and Myanmar refugees, living along the Thailand-Myanmar border.	Francis Nosten	16 December, 2014
Mahidol Oxford Tropical Medicine Research Unit (MORU)	Featuring interviews with Professor Nick White, Professor Nick Day, Professor Francois Nosten, Dr Direk Limmathurotsakul and Dr Susie Dunachie.	Nick White, Nick Day, Francois Nosten, Direk Limmathurotsakul, Susie Dunachie.	16 December, 2014
The Global Health Network	Dr Trudie Lang tells us how the Global Health Network facilitates collaboration and resource sharing.	Trudie Lang	16 December, 2014
Childhood Nutrition and Immunity	Dr Jay Berkley tells us about his work on childhood nutrition and immunity in East Africa.	Jay Berkley	16 December, 2014
The treatment of severe malaria	Professor Arjen Dondorp tells us about his work on severe malaria and the development of new therapies.	Arjen Dondorp	16 December, 2014
Tropical Medicine in Kenya	Professor Kevin Marsh tells us about his research on Tropical Medicine in Kenya.	Kevin Marsh	16 December, 2014
Artemisinin therapy for malaria	Professor Nick White talks about the future of artemisinin and other drug therapies for malaria.	Nick White	16 December, 2014
Health systems research	Governance in practice	Sassy Molyneux	16 December, 2014
Better hospitals for children	Oxford Health Systems Research Collaboration (OHSCAR)	Mike English	16 December, 2014
Between research and humanitarian	Between research and humanitarian	Francois Nosten	16 December, 2014
Diagnosis, Treatment and Disease Epidemiology - The Trefoil Knot	The Newton Abraham Lecture 2014, delivered by Professor Piero Olliaro, Newton Abraham Visiting Professor, University of Oxford.	Piero Olliaro	16 December, 2014
Microbiology in Thailand	Microbiology in Thailand	Stuart Blacksell	10 December, 2014
Infectious diseases in South East Asia	Infectious diseases in South East Asia	Nick Day	10 December, 2014
Rickettsial Disease	Daniel Paris: Rickettsial Disease	Daniel Paris	10 December, 2014
Prof Xin Lu: Women in Science	Every cloud has a silver lining: optimisism and persistence	Xin Lu	10 December, 2014
Helen McShane: Women in science	A career in juggling, organisation and guilt management	Helen McShane	10 December, 2014
Bridget Ogilvie: Women in Science	Dame Bridget Ogilvie discusses her life and illustrious scientific career, at The Wellcome Trust Centre for Human Genetics’ Women in Science series	Bridget Ogilvie	10 December, 2014
Ellie Barnes :The long road to success	A hepatologist and academic, a wife and a mother of two, Dr Ellie Barnes delighted researchers at the Wellcome Trust Centre for Human Genetics’ Women in Science talk, held on Wednesday the 20th of November 2013	Ellie Barnes	10 December, 2014
Heidi Johansen-Berg: Women in Science	Professor Heidi Johansen-Berg heads the Plasticity Group at the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB). Her research focuses on how the brain changes in response to damage, learning and experience	Heidi Johansen-Berg	10 December, 2014
Irene Tracey: Women in Science	Irene Tracey is the co-founder and director of the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB)	Irene Tracey	10 December, 2014
Work-Life Balance	Interview with Professor Peter Donnelly	Peter Donnelly, Jenny Taylor	10 December, 2014
SHARP	Lowering cholesterol in chronic kidney disease	Colin Baigent	10 December, 2014
Wider Statin Use Saves Lives	Wider Statin Use Saves Lives	Colin Baigent	10 December, 2014
Better hospitals for children	Oxford Health Systems Research Collaboration (OHSCAR)	Mike English	10 December, 2014
Health systems research	Governance in practice	Sassy Molyneux	10 December, 2014
Crohn's disease	Professor Alison Simmons tells us about her research on Crohn's disease	Alison Simmons	10 December, 2014
Asthma	Airway inflammation	Ian Pavord	10 December, 2014
Pneumococcal diseases	Genetics and genomics of Streptococcus pneumoniae	Angela Brueggemann	10 December, 2014
Better hospitals for children	Oxford Health Systems Research Collaboration (OHSCAR)	Mike English	10 December, 2014
Health systems research	Governance in practice	Sassy Molyneux	10 December, 2014
Rickettsial Disease	Rickettsial Disease	Daniel Paris	10 December, 2014
Infectious diseases in South East Asia	Infectious diseases in South East Asia	Nick Day	10 December, 2014
Microbiology in Thailand	Microbiology in Thailand	Stuart Blacksell	10 December, 2014
DNA replication and Cancer	DNA replication and Cancer	Catherine Green	10 December, 2014
Big Data	Over the past decade, data-driven science has produced enormous sets of data.	Christopher Yau	10 December, 2014
Cancer and innate immunity	Inflammatory signalling	Mads Gryd-Hansen	10 December, 2014
Stem cells and cancer	Adult gastrointestinal stem cells	Simon Leedham	10 December, 2014
Virus entry	Virus entry	Sergi Padilla-Parra	10 December, 2014
Tuberculous meningitis	Tuberculous Meningitis	Guy Thwaites	10 December, 2014
Structural biology and vaccines	Structure of viruses	Dave Stuart	10 December, 2014
Between research and humanitarian	Between research and humanitarian	Francois Nosten	10 December, 2014
Virus entry	Novel light microscopy techniques allow us to track single viruses.	Sergi Padilla-Parra	10 December, 2014
DNA replication and Cancer	DNA replication and Cancer	Catherine Green	10 December, 2014
Big Data	Over the past decade, data-driven science has produced enormous sets of data.	Christopher Yau	10 December, 2014
Between research and humanitarian	Between research and humanitarian	Francois Nosten	10 December, 2014
Prof Xin Lu: Women in Science	Every cloud has a silver lining: optimisism and persistence	Xin Lu	10 December, 2014
Part 4: A New Age of Drug Discovery	You just have to step into your local chemist to see how far medicine has come over the past 100 years. Life changing drugs, which were once unthinkable – like antibiotics, insulin and the contraceptive pill – are now commonplace.	Jonathan Webb	5 November, 2014
Part 3: Advanced technology	Just over a decade ago the face of British farming changed forever. A devastating outbreak of Foot and Mouth disease led to the enforced slaughter and incineration of over 10 million livestock across the country.	Jonathan Webb	5 November, 2014
Part 2: The history of structural biology	Understanding the function of a protein is an important step in finding out why the body succumbs to disease – but how do scientists find these proteins and figure out how they work?	Jonathan Webb	5 November, 2014
Hilary Martin	We've asked Hilary Martin from Australia why she decided to do a DPhil project in the Nuffield Department of Medicine.	Hilary Martin	28 October, 2014
Xi Li	We've asked Xi Li from China why he decided to do a DPhil project in the Nuffield Department of Medicine.	Xi Li	28 October, 2014
Sarah Dixon-Clarke	We've asked Sarah Dixon-Clarke from the UK why she decided to do a DPhil project in the Nuffield Department of Medicine.	Sarah Dixon-Clarke	28 October, 2014
Min Sun	We've asked Min Sun from China why she decided to do a DPhil project in the Nuffield Department of Medicine.	Min Sun	28 October, 2014
In Her Footsteps - Ellie Williams	Dr Mona Bafadhel interviews Dr Ellie Williams, a post-doctoral researcher in the Structural Genomics Consortium, about her career to date.	Mona Bafadhel, Ellie Williams	28 October, 2014
In Her Footsteps - Mona Bafadhel	Associate Professor Erika Mancini interviews Dr Mona Bafadhel, a Group Head in Respiratory Medicine and Honorary Consultant Chest Physician, about the highlights and challenges of having both a clinical and a research career.	Erika Mancini, Mona Bafadhel	28 October, 2014
In Her Footsteps - Erika Mancini	Dr Ellie Williams interviews Associate Professor Erika Mancini, a Group Head in the Wellcome Trust Centre for Human Genetics, about her experiences as a woman in science.	Erika Mancini, Ellie Williams	28 October, 2014
Part 1: The Building Blocks of Life	Our bodies are made up of trillions of cells but it doesn’t matter how closely you look, you still won’t see them.	Jonathan Webb	28 October, 2014
Tuberculous Meningitis	Tuberculous Meningitis	Guy Thwaites	7 October, 2014
Crohn's disease	Innate immune system	Alison Simmons	7 October, 2014
Structural biology and vaccines	Structure of viruses	Dave Stuart	7 October, 2014
Stem cells and cancer	Adult gastrointestinal stem cells	Simon Leedham	7 October, 2014
Cancer and innate immunity	Inflammatory signalling	Mads Gryd-Hansen	7 October, 2014
Asthma	Airway inflammation	Ian Pavord	7 October, 2014
Pneumococcal diseases	Genetics and genomics of Streptococcus pneumoniae	Angela Brueggemann	7 October, 2014
Helen McShane: Women in science	A career in juggling, organisation and guilt management	Helen McShane	7 October, 2014
Health systems research	Governance in practice	Sassy Molyneux	7 October, 2014
Better hospitals for children	Oxford Health Systems Research Collaboration (OHSCAR)	Mike English	7 October, 2014
Challenges when working in an overseas environment	Over several decades our researchers have carried out ground breaking work overseas, such as in East Africa and South-East Asia. Researchers based in Thailand talk about their experiences when working in stimulating and challenging environments.	Daniel Paris, Nick Day, Stuart Blacksell	2 July, 2014
Rickettsial Disease	From his research centre in Bangkok, Dr Daniel Paris tells us about the challenges posed by Rickettsia to rural populations in South East Asia.	Daniel Paris	2 July, 2014
Microbiology in Thailand	From his research group in Thailand, Dr Stuart Blacksell discusses improving the accuracy and the rapidity of tropical infection diagnosis in the field.	Stuart Blacksell	2 July, 2014
Infectious diseases in South East Asia	From Mahidol University in Thailand, Professor Nick Day talks about rural populations in Thailand and the challenges they face when confronted with infectious diseases.	Nick Day	2 July, 2014
Bridget Ogilvie: Women in Science	Dame Bridget Ogilvie discusses her life and illustrious scientific career, at The Wellcome Trust Centre for Human Genetics’ Women in Science series.	Bridget Ogilvie	11 April, 2014
Ellie Barnes :The long road to success	A hepatologist and academic, a wife and a mother of two, Dr Ellie Barnes delighted researchers at the Wellcome Trust Centre for Human Genetics’ Women in Science talk, held on Wednesday the 20th of November 2013.	Ellie Barnes	11 April, 2014
Heidi Johansen-Berg: Women in Science	Professor Heidi Johansen-Berg heads the Plasticity Group at the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB). Her research focuses on how the brain changes in response to damage, learning and experience.	Heidi Johansen-Berg	8 April, 2014
Irene Tracey: Women in Science	Irene Tracey gives a passionate insight into her career and how she balances work and life. As she puts it 'A scientific career is not an easy one to choose: it’s tough and competitive'.	Irene Tracey	8 April, 2014
Welcome to the Wellcome Trust for Human Genetics	Short film introducing the Wellcome Trust for Human Genetics	Anjali Hinch, Emma Davenport, Paolo Piazza, Mohammad Bahar, Peter Donnelly, Simon Leedham	25 February, 2014
Mahidol Oxford Tropical Medicine Research Unit (MORU)	Featuring interviews with Professor Nick White, Professor Nick Day, Professor Francois Nosten, Dr Direk Limmathurotsakul and Dr Susie Dunachie.	Nick White, Nick Day, Francois Nosten, Direk Limmathurotsakul, Susie Dunachie.	12 February, 2014
Shoklo Malaria Research Unit (SMRU)	Filmed in April 2013 at the Shoklo Malaria Research Unit (SMRU) in Mae Sot, and at the Wang Pa Free Clinic and the Mae La refugee camp, this video highlights SMRU's work among Karen and Myanmar refugees, living along the Thailand-Myanmar border.	Francis Nosten	12 February, 2014
Cambodia Oxford Medical Research Unit (COMRU)	This video introduces COMRU, the Cambodia Oxford Medical Research Unit, a collaboration between the Angkor Hospital for Children and Bangkok-based Mahidol Oxford Tropical Medicine Research Unit (MORU).	Paul Turner, Claudia Turner	7 February, 2014
Active and passive immunity to Influenza	Professor Townsend tells us about lessons to be drawn from the history of immunology in Oxford, from 1979 onwards, until his current research on active and passive immunity to influenza.	Alain Townsend	18 December, 2013
Outreach and Impact - Engaging with the community	The Nuffield Department of Medicine is committed to the pursuit of academic excellence and the positive impact of its research on the health and wellbeing of the global community.	Kate Fuller, Jen Bardsley, Simon Bushell, Wen Hwa Lee	12 November, 2013
Some final words	Professor Sir Andrew McMichael speaks about his early days in Oxford, working in immunology.	Sir Andrew McMichael	28 October, 2013
The Human Immunology Unit	The increasing globalisation of infectious disease is a major challenge to human health. The MRC Human Immunology Unit is a key player in international efforts to combat this threat, and in research into other diseases involving the immune system.	Vincenzo Cerundolo	28 October, 2013
Correlates of protection, the China Connection	Professor Xiao-Ning Xu talks about his research on emerging infectious diseases in China, from the SARS outbreak in 2003/4 to flu pandemic and HIV infection.	Xiao-Ning Xu	28 October, 2013
Time to escape	Dr Nilu Goonetilleke talks about her research within the CHAVI project (NIH Center for HIV/AIDS Vaccine Immunology).	Nilu Goonetilleke	28 October, 2013
African adventures	Professor Sarah Rowland-Jones talks about her research on HIV, first in Oxford then in Africa, in Kenya and in The Gambia.	Sarah Rowland-Jones	28 October, 2013
New immunoregulatory mechanisms	Professor Mike Lenardo speaks about early links between the NIH (National Institute of Health, USA) and the University of Oxford, and their success in setting up the NIH-Oxford-Cambridge DPhil programme.	Michael J Lenardo	28 October, 2013
A structural biologist's perspective	Professor Yvonne Jones tells us how structural biology was brought into the field of immunology in Oxford, at the Wellcome Trust Centre for Human Genetics.	Yvonne Jones	28 October, 2013
What do we measure and what do we want to learn	Professor Zinkernagel speaks about some historical and more recent aspects of immunology. Although we do know a lot, only about half of what we think we know is usually true - we just don't know which half!	Rolf Zinkernagel	28 October, 2013
Welcome and Introduction	Professor Vincenzo Cerundolo opens the Symposium with a few words about Professor Sir Andrew McMichael's achievements, past, present and future.	Vincenzo Cerundolo	28 October, 2013
Active and passive immunity to Influenza	Professor Townsend tells us about lessons to be drawn from the history of immunology in Oxford, from 1979 onwards, until his current research on active and passive immunity to influenza.	Alain Townsend	1 October, 2013
Science Oxford Live 2013 - Public Engagement	The Nuffield Department of Medicine recognises that public engagement is vital to educate, inform and build relationships with the community. Our scientists are actively engaging in open discussion, meeting people to debate, listen and learn.	Dianne Newbury, Chas Bountra, Stefan Knapp	17 September, 2013
Freeing Voices: Your questions	Specific Language Impairment affects hundreds of thousands of British children, and causes them to have difficulties speaking and understanding language.	Dianne Newbury	16 July, 2013
Drug Discovery: Your questions	How does medicine work? How are new drugs made? What role does the pharmaceutical industry play? Professors Stefan Knapp and Chas Bountra joined Science Oxford Live in spring 2013 for an evening of Scientists on the sofa, to take your questions.	Stefan Knapp, Chas Bountra	16 July, 2013
Freeing Voices	Specific Language Impairment affects hundreds of thousands of British children, and causes them to have difficulties speaking and understanding language.	Dianne Newbury	16 July, 2013

Nuffield Department of Clinical Medicine

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